Identification of genetic modifiers of CagA-induced epithelial disruption in Drosophila
نویسندگان
چکیده
منابع مشابه
Identification of genetic modifiers of CagA-induced epithelial disruption in Drosophila
Helicobacter pylori strains containing the CagA protein are associated with high risk of gastric diseases including atrophic gastritis, peptic ulcers, and gastric cancer. CagA is injected into host cells via a Type IV secretion system where it activates growth factor-like signaling, disrupts cell-cell junctions, and perturbs host cell polarity. Using a transgenic Drosophila model, we have shown...
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ژورنال
عنوان ژورنال: Frontiers in Cellular and Infection Microbiology
سال: 2012
ISSN: 2235-2988
DOI: 10.3389/fcimb.2012.00024